Influence of outer static magnetic fields on the effect of iron nanoparticle-bound quercetin in the hippocampus of laboratory rats

Author: Irakli Baratashvili
Keywords: Flavonoids, quercetin, nanoparticles, magnetic nanoparticles, magnetic field
Annotation:

Quercetin holds a special place among the natural compounds used in medicine.Despite its multiple biological effects, quercetin’s effects on the central nervous system are limited due to poor solubility in water and poor biopermeability. Quercetin has difficulty crossing the hematoencephalic barrier,so a certain strategy is developed to overcome this problem and increase the effectiveness of of quercetin’s effects on the brain. Nanotechnology-based delivery systems for compounds are a promising new approach for increasing their biopermeability. Nanoparticles are frequently used as nano-transporters for medicine, along with this the transportation of magnetic nanoparticles in the organism can be controlled via a magnetic field. The aim of the study was to determine the electrophysiological effects of systematically inserted iron nanoparticle-bound quercetin (Q-MNN) on the CA1 field of the hypocampus and assessing the influence of an outer static magnetic field (OSMF)on said effects. In the morphological experiment the influence of unilateral exposition to the temporal part of OSMF on the quantity of iron containing particles was assessed.The data acquired was statistically analysed using the software PRIZMA. The experiment showed that effects of Q-MNN on the CA1 field of the hypocampus are inhibitory in nature, they cause a decrease in the amplitudal indicator of summary neural activity in the presence of OSMF, without the OSMF injecting the same dose into a tail was ineffective. Results of the morphological research showed a statistically significant increase in the amount of iron-containing particles on the side of the brain under the influence of OSMF when compared to the contralateral side. Based on all of the above we can conclude that the outer static magnetic field causes effective transportation of the Q-MNN inserted into the tail vein to the locus of the field exposition and increases the concentration of quercin in the locus of the exposition,which in turn inhibits neural activity.