Study of release of 10-[2-(dimethylamino) propyl] phenothiazine hydrochloride from oil-in-water microemulsions

Author: natia papuashvili
Co-authors: Tinatin Butkhuzi
Keywords: surfactant, release, microemulsion
Annotation:

Annotation Many pharmacologically active substances have amphiphilic or hydrophobic nature and they have ability of self-association and interaction with membranes. The phenothiazines are widely used as drugs, they reveal surface active nature, e.g. chlorpromazine and promethazine hydrochlorides. The pharmacological activity of drugs is revealed below the critical micelle concentration, however drug accumulation still takes place at some sites. Moreover the mentioned drugs possess high first-pass hepatic metabolism. Hence drug carrier system is useful to transfer accumulated drugs into the organism. The goal of the proposed work was study of the release profile of 10-[2(dimethylaminopropyl] phenothiazine hydrochloride, PMZ) from oil in water microemulsions based on ionic surfactant sodium bis (2-ethylhexyl) sulfosuccinate (AOT). Influence of additives of non-ionic polyoxyethylene (23) lauryl ether (Brij-35) on the release process of PMZ from dialysis bags was also purpose of the presented work. Microemulsion system was formulated for PMZ delivery based on mixture AOT and Brij-35. The release profile of PMZ from dialysis bags into phosphate buffer was studied. Determination of the released PMZ was performed at several subsequent time points with treatment of samples with sodium persulfate. The oxidized colored samples were measured at 490 nm. Results obtained on the basis of PMZ-loaded microemulsions are interesting since microemulsions represent important drug delivery systems, because they encourage drug activity and bioavailability of drugs.