“A new method of nitrozilation of N-β-(p-aminobenzoic acid ethyl ester)-2,3,4,6-tetra-O-acetyl-D-glucopyranosylamine.”

Author: vika shermadini
Keywords: N-glucosylamine, nitrozilation, D-glucose
Annotation:

A n n o t a t I o n Vika Shermadini “A new method of nitrozilation of N-β-(p-aminobenzoic acid ethyl ester)-2,3,4,6-tetra-O-acetyl-D-glucopyranosylamine.” Department of Chemistry, Iv.Javakhishvili Tbilisi State University, Ilia Chavchavadze Ave. 3 The synthesis of Nitroso (N = O) group containing carbohydrate derivatives and study of their biological activity is a promising research direction to obtain new type biologically and pharmacologically active compounds. The goal of present investigation consist in synthesis of nitroso group (N=O) containing N-glucosylamine by new method and determination of biological activity potential. The formation of N-β-(p-aminobenzoic acid ethyl ester)-D-glucopyranosylamine (2) by condensation of D-glucose (1) with p-aminobenzoic acid ethyl ester in 50% methanol, in the present of acetic acid was studied at the first stage. By acetilation and further nitrozilation of N–glucozylamine (2) corresponding N-β-N-nitroso-(4-aminobenzoic acid ethyl ester)-2,3,4,6-tetra-O-acetyl-D-glucopyranosylamine (4) has been obtained. The nitrozilation was performed by a new method. The Reactions proceeds according to the following scheme: The structures of obtained compounds were established by physical-chemical methods of analysis With the help of computer program PASS Online based on the analysis of structure activity-relationships wide range of possible biological activity and toxic / side effects for synthesized glucosolamines has been determined.

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