Synthesis and Biological Activity of Some New Quinoxaline Derivatives

Author: Lekso Tlashadze
Keywords: Quinoxalines, Antimicrobial activity, Diamines, Diketones
Annotation:

New heterocyclic quinoxaline ring containing system 2-[(Benzeneiminomethyl)phenoxy]-3,7-dimethylquinoxaline and its analogues modified with benzene ring have been synthesized. The process obtaining striking product has held in four steps. On the first stage, it has been held cyclisation reaction condensing with methyl-o-phenylendiamine and ethylpiruvate in buthanol. Reaction conditions have been increasingly optimized by going up of yeld of the striking product – 3,8-dimethyl-1,2dihydroquinoxalin-2-one and its synthesis with posporus (V) oxychloride. The last gained product containing chlorine has been reacted with 4-hydroxybenzaldehyde in Acetonitrile that both have been synthesised with different aromatic amines by giving some quinoxaline ring containing schiff bases what biological activity are attentive screening of new pharmaceutical compounds.